The games use a primarily side-scrolling perspective. Spider-Man moves through urban and enclosed environments, jumps across platforms, climbs or traverses hazards, and fights enemies with close-range attacks and web-based abilities.

Progression follows a sequence of stages and story encounters. Objectives vary by level and may include reaching an exit, defeating opponents, surviving hazards, or completing a set-piece confrontation. The compilation provides access to two separate Spider-Man adventures rather than one unified campaign.

Learn the timing of Spider-Man's jump and web abilities before attempting difficult platforming sections. Keep moving during combat and use the environment to create distance from groups of enemies.

Explore each stage carefully for safer routes and useful items. Against bosses, prioritize recognizing attack patterns and strike during recovery windows rather than attacking continuously.