The game uses a first-person perspective and divides its content into three species-specific campaigns. The Marine relies on firearms, ammunition, armor, and access cards; the Alien uses speed, claws, tail attacks, and wall movement; the Predator combines advanced vision modes with ranged and close-combat equipment.

Objectives vary by campaign and include reaching locations, activating systems, rescuing or eliminating targets, and surviving hostile encounters. Levels are interconnected and maze-like, with exploration, key collection, limited resources, and sudden attacks shaping progression.

Learn each campaign's movement and resource rules before taking unnecessary fights. The Marine should conserve ammunition and search for access cards; the Alien should use darkness, walls, and speed to avoid prolonged exposure; the Predator should switch vision modes deliberately and manage energy for advanced equipment.

Map important doors, elevators, objectives, and safe routes. Save progress whenever the game permits it, because maze-like areas and sudden enemy encounters can make a missed turn costly.