Alien Rampage uses a side-view perspective. The main objective is to move through dangerous stages, defeat human and other enemies, avoid hazards, and reach the end of each level.

Players run and jump across platforms, fire weapons, collect supplies, and interact with parts of the environment. Progression is level-based, with increasingly demanding enemy placements and terrain. The emphasis is on movement, shooting, exploration, and survival rather than puzzle solving or character statistics.

• Keep moving during firefights instead of standing in open areas.
• Search platforms and side passages for weapons, ammunition, and useful pickups.
• Learn enemy placement and hazard timing before committing to difficult jumps.
• Conserve powerful ammunition for crowded encounters or tougher enemies.