The game is viewed from a third-person perspective across static 2D locations. Joe explores jungle sites, villages, laboratories, and other environments by moving between screens and examining objects.

Progress depends on talking to characters, collecting inventory items, combining or using them in the right situations, and solving environmental puzzles. Dialogue choices and object interactions provide clues, while comic set pieces and occasional dangerous encounters advance the story. The structure is primarily linear, with new areas and puzzle solutions becoming available as key events are completed.

Examine every visible object and speak with each character more than once; seemingly ordinary props often become useful later.

Keep a record of unusual items and try combinations only when the surrounding situation suggests a purpose. If progress stops, revisit earlier locations after major story events, since characters and interactions can change.