The game is viewed from a first-person perspective. Players move through interconnected levels, eliminate aliens and armed enemies, find keycards, activate switches, collect weapons and ammunition, and locate the exit. Environmental objects such as doors, security devices, lighting, and destructible scenery support exploration and puzzle solving.

Progression is level-based, with combat encounters and secret areas distributed throughout each map. The expansion uses Duke Nukem 3D's established arsenal and interactive level design. No separate role-playing progression system or character-development tree is documented for this DOS release.

Search each room carefully for switches, keycards, hidden doors, and supplies before moving on. Secret areas can provide valuable ammunition, armor, and weapons, making exploration especially useful before difficult encounters.

Conserve powerful ammunition for stronger enemies and crowded fights. Use the environment to create distance, check alternate routes when a door appears inaccessible, and save regularly because ambushes and explosive hazards can punish careless movement.