The game uses a side-view perspective. Spider-Man moves through linear stages, jumps across platforms, attacks enemies, and progresses toward level-ending encounters. Web-based movement and combat abilities complement ordinary punches and kicks.

Stages are organized around missions inspired by the film, with regular enemies, hazards, collectible items, and boss battles. Progression comes primarily from clearing missions rather than from a large role-playing system.

Learn the rhythm of each enemy before attacking. Short attack strings followed by movement are safer than standing in place, especially against groups.

Use the environment and Spider-Man's mobility to avoid damage. Against bosses, concentrate on recognizing attack patterns and strike during recovery windows rather than attacking continuously.