The game uses a side-view action perspective with platforming, combat, traversal, and occasional touch-screen activities. Each stage assigns objectives such as reaching a destination, defeating enemies, protecting a target, or confronting a villain.

Progression follows a sequence of missions tied to different Spider-Man incarnations. Players combine jumping, web attacks, dodges, and environmental movement, then face stronger enemies and bosses as the story advances.

Learn the reach and timing of web attacks before relying on close-range strikes. Keep moving during crowded fights, use the edges of platforms to control enemy approach, and look for alternate routes before committing to a jump.

Save health for boss encounters and study each boss pattern rather than attacking continuously. Explore side paths for collectibles or upgrades when the stage layout allows it.