The game uses a side-scrolling perspective. Spider-Man advances through linear stages by running, jumping across platforms, climbing or traversing obstacles, and defeating enemies with punches, kicks, and web attacks.

Stages are divided into action sequences and boss encounters. Progress depends on reaching the end of each area, surviving enemy groups, and using Spider-Man's movement abilities effectively. The campaign follows the film's story rather than offering a large open-world structure.

Learn the timing of Spider-Man's jump and web attacks before committing to close combat. Use vertical space and platforms to separate groups of enemies rather than trading hits in a crowd.

Against bosses, observe attack patterns and strike during recovery windows. Move patiently through unfamiliar sections, because rushing can cause avoidable damage or missed platforms.