The game uses a side-view perspective with platforming and combat stages. The objective is to move through Doctor Doom's environments, defeat enemies, avoid hazards, and reach the end of each section.

Spider-Man and Captain America have different abilities, so progress depends on using the appropriate hero for each encounter. Players fight, climb or traverse platforms, collect useful items, and advance through a linear sequence of levels toward the final confrontation.

Learn the differences between the two heroes before committing to a fight. Spider-Man is better suited to movement and vertical routes, while Captain America is more dependable in direct confrontations.

Advance cautiously, watch enemy patterns, and avoid trading damage unnecessarily. Explore each section for useful items, but prioritize safe positioning over rushing through hazards.