The game uses a side-scrolling perspective. Van Helsing advances through linear stages, defeats supernatural enemies, avoids hazards, and reaches an end-of-level encounter or objective.

Players can run, jump, attack with melee weapons, and use ranged weapons when available. Progression comes from completing stages, acquiring equipment, and overcoming stronger enemies and bosses rather than from a role-playing skill tree.

Levels are played as a single-player campaign with platforming sections, combat arenas, environmental obstacles, and cinematic encounters based on the film.

Learn enemy attack patterns before committing to melee attacks, especially against werewolves and larger creatures. Short, controlled attacks are safer than standing beside an enemy and repeatedly striking.

Conserve ranged ammunition for bosses and dangerous groups. Use the edges of platforms to control enemy spacing, and search each area for health or weapon pickups before moving into a major encounter.

During platforming sections, advance carefully and wait for moving hazards to complete a cycle. Bosses are generally easier when you prioritize survival and attack only during clear openings.