The game uses a third-person perspective behind Riley. Players move through connected combat areas, search for objectives, fight alien and infected enemies, and activate devices that open the route forward. Combat relies on aiming, weapon selection, shooting, and managing health and ammunition.

The campaign is mission-based and largely linear. Progress comes from reaching new areas, finding weapons or supplies, solving simple environmental obstacles, and defeating stronger enemies and bosses. There is no known multiplayer mode; the focus is a single-player story campaign.

Conserve ammunition when weaker enemies can be avoided or defeated with basic weapons, and search side paths for supplies before advancing through major encounters.

Use cover and movement during firefights, learn enemy attack patterns, and keep health in reserve for scripted battles and boss confrontations. Explore rooms carefully because progression items and route-opening devices are not always placed directly along the main path.