The game uses a side-view perspective and follows a linear sequence of platforming stages. Spider-Man moves through hazards, climbs or jumps across sections, defeats enemies, and reaches villain encounters at the ends of stages.

The player uses Spider-Man's punches and web-based abilities in close combat while managing positioning and timing. Progression is stage-based, with the objective of clearing each area and defeating its featured antagonist. It is primarily a single-player experience with no documented multiplayer mode.

Learn the timing of Spider-Man's basic attack before advancing. Many enemies are easier to handle from a controlled distance or immediately after they commit to an attack.

Conserve health by avoiding unnecessary contact with hazards and by observing boss patterns. Approach each boss encounter patiently: attack during recovery openings, then reposition rather than repeatedly trading hits.