The game uses mostly side-scrolling perspectives. Players guide the current hero through themed stages, defeat enemies, avoid hazards, collect power-ups, and reach a boss or stage goal. Simon and Dr. Wily provide the main playable actions, while several sections change the usual platforming format.

Stages draw on Konami series and may include shooting, vehicle travel, or other special sequences. Progression is linear, with new areas and encounters appearing as the adventure advances. The game supports one-player and two-player play, with the second player joining as Dr. Wily in compatible sections.

Learn the rhythm of each themed stage before rushing forward. The game changes its hazards and movement rules between areas, so conserve lives and power-ups when approaching unfamiliar sections.

In two-player play, divide attention between both sides of the screen and avoid advancing so quickly that the other character is exposed. Against bosses, prioritize safe movement and attack only during clear openings.