Players move through side-scrolling stages, defeating waves of enemies and reaching a boss encounter. The four heroes have distinct attack ranges and movement characteristics, so positioning and character choice affect how safely a stage can be cleared.

The arcade version supports solo play and cooperative multiplayer. Players use standard attacks, jumps, character-specific abilities, and environmental positioning to progress through the campaign. Defeated heroes can be replaced when the game permits, while continuing depends on the cabinet's credit settings.

Learn the reach and recovery of each hero before committing to close combat. Captain America is effective at controlling nearby enemies, while Hawkeye is safer when he can maintain distance.

Avoid standing between multiple enemies. Clear one side of the screen, use jumps to escape pressure, and save powerful abilities for bosses or dense groups. In cooperative play, separate targets so both players do not attack the same enemy unnecessarily.