The game uses a side-scrolling perspective, with each stage focusing on a particular hero and his or her abilities. Players move through hazards, defeat enemies, avoid traps, and reach the end of the level before facing a larger challenge.

Spider-Man relies on agility and web-based attacks, while the X-Men have different movement or attack properties. The stages are played in a set campaign rather than a multiplayer mode, and successful completion of the character sections advances the story toward Arcade.

Learn the hazards in each character's stage before prioritizing speed. Use the hero's specialized attack or movement ability instead of treating every section like a standard platforming level.

Conserve health where possible, watch enemy patterns, and approach boss encounters cautiously. Repeated attempts are often necessary because hazards and enemy placement can punish rushed movement.