The game uses a side-scrolling perspective and lets players choose Leonardo, Michelangelo, Donatello, or Raphael. Each turtle has different attack speed, reach, and special moves, which changes how they handle enemy groups. Progression is stage-based, with lots of basic enemies, occasional hazards, and boss battles. Controls typically revolve around movement, jumping, normal attacks, and special/combo attacks. Clearing each stage boss advances the story, and spacing plus crowd control are key to survival.

Pick the turtle whose speed and reach fit your playstyle. Against groups, keep moving sideways to avoid being surrounded. Jump-in attacks followed by retreat are useful for safe damage. Save large-area special moves for emergency situations or when enemies swarm you. Against bosses, watch for attack cues and punish after whiffs instead of overcommitting.