The game uses a side-on perspective. Players move through separate stages, defeat groups of Foot Clan enemies, avoid hazards, and fight bosses at the end of major sections.

Players can choose from multiple TMNT characters and allies, each with different attack reach, speed, and special-move characteristics. The core actions are walking, jumping, attacking, using special attacks, and interacting with enemies at close range. Cooperative multiplayer supports the arcade-style progression.

Learn the attack range and recovery time of the selected character before committing to long strings of attacks. Use jumping attacks to approach groups, then control the edge of the crowd so enemies cannot surround you.

Save special attacks for dense groups or dangerous bosses. In multiplayer, players should attack from opposite sides and avoid repeatedly striking the same target when another enemy is approaching.