The game presents side-view one-on-one fights. Players choose a fighter, defeat opponents through a series of matches, and eventually face Motaro and Shao Kahn. Standard attacks, jumping, crouching, blocking, throws, special moves, and finishing moves form the core combat system.

Arcade mode provides the main progression, while Versus mode supports matches between two players. Mortal Kombat 3 adds the Run mechanic, allowing short bursts of forward movement, and Kombos that link attacks into damaging sequences. Each fighter has distinct special moves and fatalities.

Learn the spacing and recovery of the chosen fighter before relying on long Kombos. Use blocking to absorb predictable special moves, then punish the opponent during recovery.

Save the Run meter for closing distance or extending pressure. Against Motaro and Shao Kahn, avoid reckless jumps, attack after their failed moves, and prioritize survival over elaborate finishing sequences.