The game uses a two-dimensional side view. Each stage asks the player to move from left to right, defeat Phalanx forces, avoid hazards, and reach the exit or complete a stage-specific objective.

Players can jump, attack, use a character's mutant ability, climb or traverse environmental features, and collect power-ups. The campaign changes playable characters as it progresses, with each hero offering different ways to handle enemies and terrain. The game is primarily a single-player campaign with sequential stages and no character leveling system.

Learn the strengths of each character rather than using one attack everywhere. Ranged attacks are useful against turrets and flying enemies, while melee fighters should use short attacks and retreat before being surrounded.

Explore platforms and side paths for power-ups, but avoid rushing into unfamiliar screens. Save special abilities for durable enemies or crowded areas, and watch enemy patterns before crossing hazardous sections.